You can use an antistatic wrist strap to keep yourself grounded, or touch a screw on an active light switch.
While you are looking at this side, remove the sticker towards the top of the case to reveal a Torx screw. You will need a Torx screwdriver (star) to remove this screw. In the front, there will be four small star screws. For these, you must have a small hole in the screw to get them out due to the metal sticking out the middle of them. Removing the sticker will void any warranty you have on your PlayStation.
Gently disconnect the ribbon cable and set it to the side for now.
Grab the back vents and lift up at an angle with both hands. The assembly is deceptively heavy, and dropping it could easily damage the board.
This is all the disassembly you need to do in order to clean out the inside.
Blow out all of the vents with compressed, and make sure to blow air through the heatsinks on the motherboard assembly. Clean out the USB plugs, as well as dust each individual component. Thoroughly clean the large fan so that no traces of dust remain.
If you end up removing the heatsink, it is important to replace the thermal paste.
Be sure to remember to reinsert the hard drive before turning on the PlayStation, or you won’t be able to use it.